Enzymology PhD

University of Liverpool

Our research in enzymology focuses on understanding the structure, function and mechanisms of the multitude of enzyme families employed by biological systems. By investigating how different enzymes, along with their catalytically-inactive ‘pseudoenzyme’ counterparts, drive biochemical reactions, we aim to uncover key insights into cell signalling, metabolic pathways and disease mechanisms. This includes the potential applications in drug development, biotechnology, and industrial processes.IntroductionThe Institute of Systems, Molecular and Integrative Biology (ISMIB) was established to integrate cutting-edge and clinical research across the Faculty of Health and Life Sciences. Programmes of work across ISMIB are varied and are led by world experts in their fields.The Department of Biochemistry, Cell and Systems Biology has excelled in teaching and research since 1902, when the world’s first Chair of Biochemistry was established in Liverpool. Our integration of biochemical enzymatic and signalling research with systems-based studies, including multi-omics, data analysis, structural biology, synthetic biology, and artificial intelligence, makes us a global leader. This is further supported by top-tier shared research facilities and our commitment to sharing discoveries.We offer intensive PhD programmes with exposure to diverse technologies in enzymology. Research is multidisciplinary, with strong collaborations across the Institute and wider University, spanning physical, chemical, and clinical sciences. Our research programmes are supported by world-class facilities, including the Centre for Genomic Research, Centre for Proteome Research, Centre for Metabolomics Research, and Computational Biology Facility.Research topicsTopics relevant to enzymology include:BiochemistryCell signallingDrug discoveryPlant biochemistryBiotechnologyStructural biologyComputational biologyChemical biologyMultiomicsSystems biology.Note: Enzymology MPhil / MD also available