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With more than 50,000 cases diagnosed in the UK each year and 1.7 million worldwide, breast cancer is the most common form of cancer in women. Approximately 20-25 per cent of patients with hereditary breast cancers and 5-10 per cent of patients with any type of breast cancer have a BRCA mutation.
BRCA genes repair damaged DNA and normally prevent tumour development. However, mutations of these genes may lead to certain cancers, including breast cancers.
It is hoped that the use of the drug in breast cancer patients will now also be approved by the European Medicines Agency so that patients throughout Europe can benefit from its life-extending properties.
In 2005, Professor Thomas Helleday and his team of researchers at the University of Sheffield demonstrated how PARP inhibitors could be used as a tailored treatment for patients with BRCA2 mutations, which are seen in both hereditary ovarian and breast cancer.
The discovery was patent protected and licensed to pharmaceutical company Astra-Zeneca who continued the development process and undertook successful clinical trials.
Professor Helleday said: “This is fantastic news for breast cancer patients. I am delighted that after all the hard work carried out since 2005 when we made the original discovery, patients are now benefitting from this new therapy.
“This could not have been achieved without the support of Yorkshire Cancer Research and the University of Sheffield. It is a fantastic example of academic institutions and charities collaborating to fund pioneering research.”
A leading UK university with a global reputation - ranked in the World Top 100 by the 2018 QS World Rankings. Students will learn in a variety of ways, including lectures, seminars, tutorials and independent study.
Depending on the course, students might take part in fieldwork, group work, student-led seminars and group projects. Some work may be supplemented with online lessons. All these approaches encourage students to work independently and be curious about the world – skills that will set up for life and work.
The University’s academic staff are at the forefront of their fields meaning students are taught and supervised by experts. The staff are highly respected writers, critics, thinkers and technical innovators who regularly publish their work in international journals. They are committed to developing skills and ensuring students get the best out of their time studying in Sheffield.
Sheffield offers more than 370 undergraduate courses covering over 75 different subject areas.
A degree from The University of Sheffield is recognised internationally and gives students an edge in the global careers market.
The University of Sheffield International College is a dedicated facility where international students come to prepare for the challenges of academic life, whether they are preparing for undergraduate or postgraduate study. The College is focused on helping students with English as a second language and different educational backgrounds. Students will learn a specialist subject matter, improve their English language skills, and gain the required study skills needed to succeed in their main study programme.
All applicants are required to have an internationally recognised English language qualification such as IELTS or equivalent. The minimum score that is accepted for entry, in line with UKBA regulations, is IELTS 6.0 or equivalent. Standard XII English Language with at least 70% or above is also accepted.
The University offers the following scholarships to all international students starting their studies in the Faculties of Engineering, Science, Arts and Humanities, and the School of Law in September 2018:
Sheffield also offers the following scholarships to international students that meet the eligibility and award criteria:
These are available for students starting any undergraduate course at the University of Sheffield in September 2018.
As a premier league university with an outstanding reputation for teaching and research, the University offers the following range of scholarships to students of high academic ability for September 2018 entry.
Student’s potential as a graduate starts with choosing Sheffield. Graduating with a first or 2:1 from a Russell Group university will impress future employers and The University of Sheffield offers many more opportunities for personal and professional development.
The University’s relationships with employers enables students to gain work experience from the start of their degree, choose to do a placement year or a summer internship and students will develop a range of transferable skills.
Throughout the studies in Sheffield, the dedicated Careers Service helps students develop career goals and offers help on how to achieve them. Its specialist advisers will show students what employers are looking for and how to market themselves, not just through skills and subject knowledge but also achievements and experience alongside their studies. Opportunities will be provided throughout the course for students to meet employers offering placements, jobs and work experience.
Recent placements include: AstraZeneca, Deloitte, Ernst & Young, ESPN, Fujitsu, IBM, the NHS, Rolls-Royce and Unilever. Some are in Sheffield, while others are across the country in cities including London. Students can also spend their placement year working overseas.
Sheffield is ranked top in in the north of England for graduate prospects, according to The Times and Sunday Times Good University Guide 2018. 82.6 per cent of graduates secure graduate-level employment or further study after finishing their studies.
The University’s graduates achieve amazing things across the globe, using their degrees to make a positive impact on society and change the world for the better.
Send your questions to learn more about University of Sheffield
